The crystal structure of E. coli dihydrofolate reductase (DFR) ... | Filo
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Folate can be “normal” in blood—and low in the brain. Kids with cerebral folate deficiency may have folate receptor antibodies that block transport into the brain. Result: normal serum, low CSF, and symptoms tied to impaired neurotransmitter production. In today’s episode, pediatric neurologist Dr. John Gaitanis breaks down: How folate actually gets into the brain (and why transport matters) Why some kids regress or develop tics/OCD despite “normal” labs Practical steps families and clinicians c
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Folate can be “normal” in blood—and low in the brain. Kids with cerebral folate deficiency may have folate receptor antibodies that block transport into the brain. Result: normal serum, low CSF, and symptoms tied to impaired neurotransmitter production. In today’s episode, pediatric neurologist Dr. John Gaitanis breaks down: How folate actually gets into the brain (and why transport matters) Why some kids regress or develop tics/OCD despite “normal” labs Practical steps families and clinicians c
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Folic acid is the synthetic form of folate. Over 50% of the population has MTHFR gene mutations and cannot process folic acid properly which then becomes toxic to the body. That’s because MTHFR mutations have a hard time converting folic acid so the body can use it. It’s all about homocysteine. MTHFR SNPs lack the enzymes to break down the levels in the body. Folate (natural form of B9) is needed to do this. Folic acid (synthetic form of B9) becomes toxic to the body. Symptoms of MTHFR mutations
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Folic acid is the synthetic form of folate. Over 50% of the population has MTHFR gene mutations and cannot process folic acid properly which then becomes toxic to the body. That’s because MTHFR mutations have a hard time converting folic acid so the body can use it. It’s all about homocysteine. MTHFR SNPs lack the enzymes to break down the levels in the body. Folate (natural form of B9) is needed to do this. Folic acid (synthetic form of B9) becomes toxic to the body. Symptoms of MTHFR mutations
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