Hipertrofia Muscular - mTOR e Síntese Proteica A hipertrofia muscular é um fenômeno celular, logo é resultado de ativações de vias de sinalização específicas, dentre as quais uma que se destaca é a via mTOR. A proteína mTOR é um proteína reguladora chave de vários processos celulares, dentre eles destacam-se a proliferação, crescimento e sobrevivência celular, na realidade, essa é uma via de convergência de várias vias anabólicas (Iniciadas pelo GH, insulina, IGFs, MGFs, aminoácidos e testoteron
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Hipertrofia Muscular - mTOR e Síntese Proteica A hipertrofia mus…
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mTOR (mechanistic Target Of Rapamycin) senses nutrients and decides whether your cells should grow or repair. High nutrients → mTOR up → Growth mode Low nutrients → mTOR down → Maintenance mode Here's why it matters: The maintenance state (low mTOR) is associated with slower aging. Animals with reduced mTOR activity tend to live longer and remain healthier. What affects mTOR: Fasting/caloric restriction (lowers it) Protein intake (raises it) Exercise (raises it acutely) Rapamycin (inhibits it) Y
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Rob Bozada, FRSC on Instagram: "mTOR (mechanistic Target of Rapamycin) is a central regulator of muscle growth and protein synthesis. Some highlights as far as muscle physiology and gene expression are concerned are as follows: 💪🏼Muscle Physiology: * mTORC1, the active complex in muscle, is triggered by: * Mechanical tension (resistance training) * Amino acids (especially leucine) * Insulin and IGF-1 signaling * Once activated, mTORC1 promotes protein synthesis by stimulating: * p70S6 kinase (
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