Dec 17, 2025 · Cell reprogramming is the process of reverting mature, specialised cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re-establishment of epigenetic …

In biology, reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development or in cell culture. [1] Such control is also often …

This Review discusses the evolution of direct reprogramming from a transcription factor-based method to a small-molecule-driven approach, the recent progress in enhancing reprogrammed cell …

Mar 27, 2025 · This review summarizes the recent advances in cell reprogramming mediated by transcription factors or chemical molecules, followed by elaborating on the important roles of …

In addition to problems of safety, reprogramming thus far been a very inefficient process – only about one in every 1,000 mature cells is successfully reprogrammed.

Dec 2, 2025 · Cell reprogramming is the act of reverting mature, specialised cells into induced pluripotent stem cells, also known as iPS cells. This process requires a stem or progenitor cell …

Reprogramming is the result of large-scale changes in the epigenetic profile and gene-expression pattern of a cell, induced by the over-expression of key transcription factors, which regulate and …

Feb 2, 2024 · Here we describe novel approaches in direct reprogramming that address these challenges. Extracellular signaling pathways (Receptor tyrosine kinases, RTK and Receptor …

In this review, we focus mainly on direct reprogramming strategies by transcription factors and highlight the variables that contribute to cell fate conversion outcomes.

Sep 30, 2024 · Here, we review and compare currently available reprogramming approaches, including transcription factor-based methods and small molecule-based approaches, to derive pluripotent cells …