A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. N -acetylneuraminic acid, NANA) linked on the sugar chain.

In this review, we will summarize ganglioside functions that are crucial to maintain brain health, we will review changes in ganglioside levels that occur in major neurological conditions and we …

Understanding the regulatory mechanisms governing ganglioside biosynthesis is essential for elucidating their roles in health and disease and may provide insights into therapeutic …

The term ganglioside refers to the large family of glycosphingolipids that contain sialic acid linked to the oligosaccharide core. In humans, most ganglioside sialic acid is in the N -acetyl form, as …

Altered ganglioside levels or profiles are associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, where they may contribute to neuronal dysfunction and …

Oct 6, 2020 · In this review, we will summarize ganglioside functions that are crucial to maintain brain health, we will review changes in ganglioside levels that occur in major neurological …

The expression of gangliosides in the nervous system is developmentally regulated and is closely related to the differentiation state of the cell. Ganglioside biosynthesis occurs in intracellular …

Dec 15, 2025 · This study proposes a novel mechanism for tau internalization and posits that reducing ganglioside sialylation may be a promising strategy for hindering the spread of tau …

Structurally homogenous gangliosides and ganglioside probes that are modified by isotopes, fluorescence, chemical reporter groups, photoaffinity, or affinity ligands are valuable tools for …

The diversity of ganglioside species is reflected in their structural complexity, with GM1, GD1a, GD1b, and GT1b representing the four most abundant complex gangliosides in the nervous …