We found that microglial CD36 contributes to post-ischemic inflammasome activation and IL-1β production, and that conditional microglial or EC CD36 deletion reduces ischemic brain injury.

Jan 29, 2025 · In this study, we investigated the role of LDs accumulation in microglia for SCI, as well as the regulatory mechanism of CD36 in microglia lipophagy during LDs elimination in …

Sep 14, 2007 · The pattern recognition receptor CD36 initiates a signaling cascade that promotes microglial activation and recruitment to β-amyloid deposits in the brain.

Jul 1, 2021 · The data identify microglial and endothelial CD36 as critical upstream components of the acute inflammatory response to cerebral ischemia and viable putative therapeutic targets.

Jun 5, 2024 · This study illuminates that the suppression of CD36 mitigates WMI by constraining microglial polarization towards the pro-inflammatory phenotype through the down-regulation of …

While effects of CD36 in mediating cell-cell interactions would require further investigation, our results show that altered receptor interactions in microglial cells affect the modes of microglial …

Apr 17, 2021 · We conclude that microglial CD36 is a key determinant of post-ischemic IL-1β production by regulating caspase-1 activity, whereas endothelial CD36 is required for the full …

This study illuminates that the suppression of CD36 mitigates WMI by constraining microglial polarization towards the pro-inflammatory phenotype through the down-regulation of the Traf5 …

To address this challenge, here we propose to examine mechanisms to modulate the efficacy of AM NPs by tuning their binding affinity to CD36 to inhibit the initial aSYN–CD36 interactions …

Sulfo-N-succinimidyl oleate sodium (SSO), a CD36 inhibitor, has been shown to promote the lipophagy of microglial cells in SCI mice and PA-treated BV2 cells, which enhanced LDs …