Alagille syndrome (ALGS) is a genetic disorder that affects primarily the liver and the heart. Problems associated with the disorder generally become evident in infancy or early childhood.

May 19, 2000 · Alagille syndrome (ALGS) is a multisystem disorder with a wide spectrum of clinical variability; this variability is seen even among individuals from the same family.

Sep 11, 2025 · Alagille syndrome is a genetic condition that causes malformed, narrowed or missing bile ducts. It can also affect your heart and other organs.

Alagille syndrome — also known as Alagille-Watson syndrome, syndromic bile duct paucity and arteriohepatic dysplasia — is an inherited liver disorder that also affects the heart, eyes, bones, …

Alagille syndrome is a genetic disorder that can affect the liver, heart, and other parts of the body. One of the major features of Alagille syndrome is liver damage caused by abnormalities in the bile ducts.

Alagille syndrome is an inherited condition in which bile builds up in the liver because there are too few bile ducts to drain the bile. This results in liver damage. Your liver makes bile to help remove waste …

Feb 27, 2025 · Alagille syndrome is a genetic disorder that primarily causes cholestatic liver disease but is also associated with defects in multiple other organ systems. The clinical manifestations and …

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Jan 30, 2024 · Common symptoms, which often develop during the first three months of life, include blockage of the flow of bile from the liver (cholestasis), yellowing of the skin and mucous membranes …

Mar 6, 2026 · Alagille syndrome (ALGS) is an autosomal-dominant multisystem disorder caused by pathogenic variants in the JAG1 or NOTCH2 genes that disrupt the Notch signalling pathway, which …