Cryo-EM structures reveal conformational dynamics behind AP-4 membrane trafficking

Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...
eLife

Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. This manuscript by the ...
GEN

Dissecting the CAR T-Cell Membrane Using the Proximity Network Assay

Chimeric antigen receptor (CAR) T cell-based therapy has greatly improved cancer treatment, especially for hematologic cancers. 1 By providing T cells with synthetic receptors that target tumor ...
Frontiers

Hartnup disease-causing SLC6A19 mutations lead to B0AT1 aberrant trafficking and ACE2 mis-localisation implicating the endoplasmic reticulum protein quality control

1 Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates 2 ASPIRE Precision Medicine Research Institute Abu Dhabi, ...
ahajournals.org

GPLD1 Attenuates Heart Failure via Dual-Membrane Localization to Inhibit uPAR

Despite the established role of GPLD1 (glycosylphosphatidylinositol-specific phospholipase D1) in age-related impairments, its involvement in cardiovascular diseases remains unclear. We analyzed GPLD1 ...
The American Journal of Managed Care

Multicancer Detection Assays Remain Largely Elusive for Early-Stage Disease Detection

Multicancer early detection (MCED) assays use circulating tumor DNA, methylation patterns, RNA, and protein biomarkers to detect multiple cancer types early, potentially revolutionizing cancer ...
BioSpace

OmniAb Showcases Innovative High-Throughput Single B-cell Screening xPloration® Platform at the 21st Annual PEGS Boston Summit

xPloration Maximizes Impact for OmniAb’s Partners through Efficient and Precise Mining of Immunized Antibody Repertoires EMERYVILLE, Calif.--(BUSINESS WIRE)--OmniAb, Inc. (NASDAQ: OABI) today ...