Since launching her own lab at Yale in 2018, Candie Paulsen and her research team have been working to crack a longstanding mystery: How are pain signals regulated in the human body? And why do they ...

Since launching her own lab at Yale in 2018, Candie Paulsen and her research team have been working to crack a longstanding mystery: How are pain signals regulated in the human body? And why do they ...

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of heart function. While some CaMKII activity is beneficial, excessive, or persistent, CaMKII can lead to heart damage.

Twenty years after she was convicted of killing her four children, Kathleen Folbigg has walked free. The pardon hinged on key scientific and medical evidence presented at an inquiry that began last ...

Arrhythmia, when left unchecked, can be life-threatening. Abnormalities in CALM genes, which are responsible for producing the ubiquitous calcium-binding messenger protein calmodulin – or CaM -- are ...

Using cryo-electron microscopy and mass spectrometry, researchers from PSI have deciphered the structure of an ion channel found in the eye while it interacts with the protein calmodulin – a structure ...

Calmodulin (CaM) directs the Ca 2+ response in virtually all eukaryotic cells. It binds hundreds of targets that include ion channels. Different properties from each of its four unique Ca 2+-binding ...

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China The calmodulin binding transcription activator (CAMTA) is a transcription ...

Calcium-calmodulin (CaM) signaling plays an essential role within and outside of the nervous system. Moreover, it is conserved from plants to humans. While a lot is known about the mechanisms of ...

Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. We showed previously that calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), a ...

A team of scientists has discovered that the toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells. SidJ hijacks human protein ...

Calcium/calmodulin (Ca 2+ /CaM)-mediated signaling plays important roles in sensing and transducing environmental stimuli and developmental cues (Du and Poovaiah, 2005; Poovaiah et al., 2013), plant ...