Reflecting the urgent need for effective therapies to manage this common chemotherapy side effect. CIPN affects 30–40% of ...

Tumours boost their own growth by attracting and then commandeering nearby sensory neurons, a study finds. By ‘plugging into’ ...

BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...

Researchers from The University of Texas at Dallas and their international colleagues have determined the molecular signature of human sleeping -­ or silent -­ nociceptors: sensory neurons that are ...

The NOD-like receptor protein 3 (NLRP3) inflammasome is a validated target for anti-inflammatory drug development. Upon activation by internal and external stimuli, NLRP3 mediates the release of ...

Scientists have mapped the sensory neurons in bone for the first time, and identified their dual role in reporting and ...

NLRP3 is a validated anti-inflammatory target that mediates the release of proinflammatory cytokines IL-1β and IL-18, and ISM5059 targets systemic inflammatory conditions by targeting NLRP3 and ...

A heart attack activates stress circuits in the brain that evolved for survival but can amplify inflammation, disrupt healing ...

Analysis from continued follow-up of Phase 1/2 clinical trial data in Hunter syndrome (MPS II) reinforces potential for tividenofusp alfa ...

A neurological-based rehabilitation system to address phantom limb syndrome has been registered by the FDA as a Class II Software as a Medical Device, the manufacturer said in a press release.The ...

Orphan Drug Designation applies to approximately 50,000 Patients who predominantly suffer from severe chronic pain due ...