The adenosinergic system, principally mediated by four subtypes of G-protein-coupled adenosine receptors (A1, A2A, A2B and A3), plays a pivotal role in the regulation of immune responses.

A 1 AR Brain (cortex, hippocampus, cerebellum), spinal cord, eye, adrenal gland, atria, liver, kidney, adipose tissue, salivary glands, esophagus, colon, atrium and ...

Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its role ...

A recent study by researchers at the University of Florence and collaborators has demonstrated the efficacy of MRS-3997, a dual adenosine A2A/A2B receptor agonist, in reducing brain damage and ...

Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic dissection of rapid antidepressant action identifies adenosine ...

Future Neurology. 2012;7(3):307-327. Adenosine belongs to the group of neuromodulators. It modulates the activity of the nervous system at a cellular level, presynaptically by inhibiting or ...

A key protein, HOXD13, helps melanoma tumors grow and evade the immune system by boosting blood supply and blocking cancer-fighting T cells. Disabling it shrinks tumors and reopens the door for the ...

Biointervene Inc. has described adenosine analogues acting as adenosine A3 receptor (ADORA3) agonists reported to be useful for the treatment of mild cognitive impairment, diabetic neuropathy, ...