Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with ...

The result is one molecule that can be both a checkpoint degrader and a cancer vaccine ( Nature 2026, DOI: 10.1038/s41586-025 ...

The advent and proliferation of targeted modalities represent an evolutionary leap forward in drug development. By binding ...

Proteasomes are molecular machines for breaking down proteins. Drugmakers are working to coopt this process with targeted therapies. This story was originally published on BioPharma Dive. To receive ...

Targeted protein degradation has moved well beyond its prologue more than 20 years ago. 1 The number of publications describing different PROTACs (PROteolysis TArgeting Chimeras), molecular glues, and ...

Targeted protein degradation (TPD) is transforming drug discovery by leveraging the cell’s natural protein disposal systems to eliminate disease-causing proteins. Innovators are making rapid and ...

Synthesizing new proteins – the building blocks of biological life – is a scientific field of immense potential, and a newly developed AI model promises to create instructions for new proteins way ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

Holly has a degree in Medical Biochemistry from the University of Leicester. Her scientific interests include genomics, personalized medicine, and bioethics.View full profile Holly has a degree in ...