A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten -- ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

In multicellular organisms, the earliest products of transcription, called pre-mRNAs, undergo a molecular makeover before shipping out to the cytoplasm, where the modified mRNAs spell out the recipe ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...