This is a preview. Log in through your library . Abstract The replisome is a multiprotein machine that is responsible for replicating DNA. During active DNA synthesis, the replisome tightly associates ...

DNA replication is essential to all life, yet many basic mechanisms in that process remain unknown to scientists. The structure of the replisome--a block of proteins responsible for unwinding the DNA ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Scientists look at the base pairs that compose the "rungs" of the DNA ladder to determine a genome's sequence. The success of E. coli bacteria depends on their ability to multiply very rapidly by ...

It may be time to update biology texts to reflect newly published data from a collaborative team of scientists at Rockefeller University, Stony Brook University, and the U.S. Department of Energy’s ...

These cartoons show the old "textbook" view of the replisome, left, and the new view, right, revealed by electron micrograph images in the current study. Prior to this study, scientists believed the ...

Despite the importance of DNA replication, numerous aspects of this process are still poorly understood. One fundamental question is: how do replication forks efficiently progress through chromatin?

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Reactive oxygen species (ROS) were long regarded as harmful by-products of mitochondrial metabolism, but growing evidence—including our own—shows that ROS also signal to core processes such as ...

Until now, the exact configuration of the replisome, a protein complex that unzips and copies DNA, has been unknown. After taking the first pictures of this complex, researchers were surprised to find ...