A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing ...

Thought too hard to do, a new platform evolved proteins in mammalian cells, which could help researchers design drugs that work better in humans. “There are many, many examples, both published and ...

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...

In a remarkable leap forward for synthetic biology, the AI model ESM3, developed by Evolutionary Scale, has achieved a significant milestone. By simulating half a billion years of evolutionary ...

Protein evolution plays a key role in many biological processes that are essential for life – but what does it have to do with physics? Schematic overview of procedure used to generate simulated ...