Orphan Drug Designation applies to approximately 50,000 Patients who predominantly suffer from severe chronic pain due ...

Potassium channels are essential membrane proteins that enable the selective and rapid transport of K⁺ ions, a process fundamental to cellular excitability and signal transduction. Recent research has ...

Researchers have discovered a new mechanism for potassium channel inhibitor entry, which could improve the specificity of drugs targeting the channel. Upon binding to calcium ions, BK channels allow ...

This article and associated images are based on a poster originally authored by Sivakumar, M, Smith, E, Shumate, J, Scampavia, L, Spicer, T, Hernandez, D and Peters, C and presented at ELRIG Drug ...

Following this design principle, the researchers create angstrom-scale pores in bi-layer graphene sheets, and decorate the two pore edges with twisted rings of carbonyl groups. The artificial ion ...

A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS. The novel mutation ...

A study published in the 19 October Nature shows that one subunit of a potassium channel has a pivotal role in controlling vascular smooth muscle tone. This raises the possibility that defects in this ...

Researchers find blocking the KCNB2 gene can slow tumor growth, paving the way for next-gen treatments for childhood brain cancer. Scientists at The Hospital for Sick Children (SickKids) have ...

Voltage-gated potassium (Kv) channels play an important role in modulating the electrical activity of cells, opening in response to changes in membrane voltage and allowing potassium ions to escape.

Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumour in children ...