In genomes, three letters or bases of DNA encode an amino acid. Amino acids are then strung together by the cell to create proteins. There is some redundancy in that genetic code, but there are single ...
Artificial intelligence firm Google DeepMind has adapted its AlphaFold system for predicting protein structure to assess whether a huge number of simple mutations are harmful. The adapted system, ...
Proteins are like Spider-Man in the multiverse. The underlying story is the same: each building block of a protein is based on a three-letter DNA code. However, change one letter, and the same protein ...
Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the ...
Researchers have discovered that mutations affect protein stability following remarkably simple rules. The discovery has profound implications for accelerating the development of new treatments for ...
The team developed a high-throughput imaging platform to assess the influence of nearly 3,500 mutations on protein location. They found that roughly one in six disease-causing mutations led to ...
Viruses need to infect their hosts’ cells in order to replicate. But the hosts tend to not want these pathogens utilizing their resources, killing their cells, and putting their lives in danger. As ...
A comprehensive analysis of over 500,000 human protein variants reveals that 60% of disease-causing missense mutations reduce protein stability In a recent study published in Nature, researchers used ...
Make way, APP, PS1, PS2. A fourth gene, SORL1, is joining you on the podium of infamy. For years, researchers have steadily built the case that SORL1 is the fourth familial, sometimes even ...
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