HIEs were used to identify why the growth of norovirus in culture stops and to determine methods to maintain growth.

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Scientists inch closer to an autologous diabetes cell therapy that dodges the challenge of immune rejection, creating insulin-producing cells from the lining of the gut. As of 2025, an estimated 9.5 ...

A new study, led by Professors Mashaghi and Clevers from Leiden University and Hubrecht Institute in the Netherlands, has introduced a novel approach using intestinal organoids to uncover the ...

This postdoctoral researcher examines how cellular metabolism and disease progression intersect in Crohn’s disease.

In a proof of concept that may reshape the treatment landscape for insulin-dependent diabetes, scientists have demonstrated that human stomach cells can be reprogrammed to secrete insulin—potentially ...

A human intestinal organoid, displaying typical ‘budding crypts’ and a central ‘villus-like’ domain. The main intestinal cell types are shown in green, blue, red and purple. Membranes are yellow and ...

Organoids are three-dimensional, miniaturized, and simplified versions of organs produced in vitro from stem cells or organ-specific progenitor cells. They recapitulate key structural and functional ...

Mini-stomach models that produce acid have been grown from human gastric cells, helping researchers study rare digestive diseases and test precise treatments.