Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, a process that is termed glucose toxicity. Our perspective about glucose toxicity as it ...

These authors evaluated the GRI conjugate according to its capacity to replace both prandial and basal needs using laboratory-based assessments and preclinical mouse and mini-pig models (Figure 1).

Working with heart muscle cells from diabetic rats, scientists at Johns Hopkins have located what they say is the epicenter of mischief wreaked by too much blood sugar and used a sugar-gobbling enzyme ...