Marine microorganisms have emerged as promising biological factories for the synthesis of valuable fatty acids, notably polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and ...

The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...

An investigational oral fatty acid synthase (FASN) inhibitor was associated with significant improvements in metabolic dysfunction-associated steatohepatitis (MASH) in a phase II clinical trial. In ...

Schematic representation of biosynthesis in a cell (top) and in the laboratory (bottom). The designer enzyme shortens the chain length of the fatty acid. FRANKFURT. Whether laundry detergents, mascara ...

Pensini et al. sought an efficient way to remove these contaminants. Using a combination of experiments and simulations, the researchers uncovered how fatty acids can help separate and trap pollutants ...

The monoclonal antibody Herceptin dras­tically improves prog­nosis for patients with HER2+ breast cancer. But if the primary tumor metasta­sizes to the brain, it often fails to respond to treatments.