Euan Ashley's lab explores the intricate interactions of gene variants. Tiny "typos," or genetic mutations, can sneak into ...
In a recent study posted to the bioRxiv* pre-print server, researchers used deep mutational scans to measure the effect of each amino-acid mutation in the receptor-binding domain (RBD) of severe acute ...
In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of epistatic interactions on the angiotensin-converting enzyme-2 (ACE2) affinity in the severe acute ...
Imagine your doctor calls you to discuss the results of your genetic testing. They tell you your results indicate you are highly likely to develop Alzheimer's disease. But not to worry, because they ...
Why evolutionary genetics does not always add up / Edmund D. Brodie III -- Beyond the average : the evolutionary importance of gene interactions and variability of epistatic effects / Patrick C.
Detecting epistatic selection with partially observed genotype data by using copula graphical models
In cross-breeding experiments it can be of interest to see whether there are any synergistic effects of certain genes. This could be by being particularly useful or detrimental to the individual. This ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 4 (January 25, 2022), pp. 1-10 (10 pages) The emergence of new variants of severe acute respiratory ...
When combined, the effects of mutations in different genes often deviate from what would be expected by looking at them separately. Researchers at the University of València in Spain have shown that ...
Professor, David J. Freelander Chair in AIDS Research, Program in Molecular Medicine, Biochemistry & Molecular Biotechnology, University of Massachusetts Medical School During the first year of the ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results