Increased lipid content in the steatotic liver induces chronic endoplasmic reticulum (ER) stress, mainly via the alteration of Ca 2+ homeostasis Classic ER stress responses such as ER-associated ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

In solid tumours, low vascularization exposes actively dividing cells to nutrient deprivation and hypoxia that affect the endoplasmic reticulum (ER) function in the folding and maturation of secretory ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

The endoplasmic reticulum plays a more important role in type 2 diabetes and its complications than previously believed, new research suggests. To make their discovery, scientists identified several ...

Alexander Chernorudskiy, Ersilia Varone, Sara Francesca Colombo, Stefano Fumagalli, Alfredo Cagnotto, Angela Cattaneo, Mickael Briens, Mireille Baltzinger, Lauriane ...

Calcium is one of the most important minerals for body as well as cellular functions.But the way it controls the quality of ...

Established in 1926, Plant Physiology is an international journal devoted to physiology, biochemistry, cellular and molecular biology, genetics, biophysics, and environmental biology of plants. Plant ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed -- for instance in ...

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An equally precise biological process in living cells gives rise to proteins, the large biomolecules essential for life. Proteins begin life as long strings of amino acids that must fold into the ...