Glutathione balance in the ER, controlled by SLC33A1, is essential for proper protein folding and disease prevention.

The endoplasmic reticulum (ER) is central to protein synthesis, folding and modification, ensuring that the proteome of a cell remains functional and balanced. When the ER is overwhelmed by an ...

Zinc is an essential trace element that controls myriad biological processes. The delicate balance of its concentration in ...

A study in the Chinese Journal of Natural Medicines reports that Zishen Huoxue Decoction (ZSHX) mitigates myocardial ischemia-reperfusion (I/R) injury by reprogramming endoplasmic reticulum ...

How does the ER prevent misfolded proteins? Researchers identify the SLC33A1 transporter as a critical glutathione regulator ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

Calcium (Ca 2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, is ...

Researchers have discovered that zinc levels in the endoplasmic reticulum (ER) directly influence redox enzymes essential for proper protein folding. The study found that excess zinc disrupts Ero1 ...

Rockefeller researchers previously discovered several new important tasks that the antioxidant glutathione manages throughout the body. Now they’ve found that glutathione maintains the smooth ...

“A lot of what we’ve assumed based on the tools that we had really isn’t true,” study coauthor Craig Blackstone, a cell biologist at the National Institute of Neurological Disorders and Stroke, told ...

In the past several years, Rockefeller University's Kivanç Birsoy and his team in the Laboratory of Metabolic Regulation and ...