For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...
The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...
Vijay K. Kuchroo, PhD, DVM, of the Gene Lay Institute of Immunology and Inflammationof Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School and the Ann Romney Center ...
Understanding how cells transform into specialized types during human development is a central challenge in biology. This complex process, known as cell differentiation, holds the key to understanding ...
A genome-wide CRISPR study maps 331 genes essential for early brain development, identifying PEDS1 as a new ...
A large genetic screen has revealed how stem cells transform into brain cells, exposing hundreds of genes that make this ...
The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...
Discover how human adipose tissue can be transformed into functional organoids representing all three germ layers—mesoderm, endoderm, and ectoderm—using a novel, streamlined method. This new study ...
Researchers at the University of British Columbia developed a reliable method to produce helper T cells from stem cells by precisely tuning Notch signaling, enabling scalable, off-the-shelf immune ...
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