Harvard Medical School researchers have uncovered crucial insights into how an emerging class of antiviral drugs works.

Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate primase-Pol α (PP) activity at telomeres constitutively, and at other genomic locations under ...

The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3′ OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by ...

DNA replication is a complicated affair: Proteins must identify where on DNA to start replicating, unwind the double helix, synthesize a primer, and then elongate the DNA strand from the end of that ...

– Data from both ABI-5366 and ABI-1179, novel long-acting helicase-primase inhibitor candidates for recurrent genital herpes, to be presented – – Poster presentation highlights key preclinical data ...

In the early 1990s, Jacqueline Barton, the John G. Kirkwood and Arthur A. Noyes Professor of Chemistry at Caltech, discovered an unexpected property of DNA--that it can act like an electrical wire to ...

The herpes simplex virus (HSV) causes cold sores and genital lesions and with the exception of acyclovir (an inhibitor of the viral DNA polymerase), there are currently no drug treatments available.

Undergraduate biology students could be forgiven for thinking that scientists have DNA replication all figured out. After all, textbooks present the models of replication so matter-of-factly that it's ...