Several specific genetic mutations have been associated with colorectal cancer (CRC) and dysplasia in patients with ulcerative colitis (UC). [1] Many of these genetic alterations are unique to ...

In about 5–10% of colorectal cancer patients, hereditary factors play a role, with higher percentages among younger patients.

A new study found that at least 70 genetic mutations are involved in the formation of colon cancer, significantly more than was previously thought, according to a news release by UT Southwestern ...

Dr. Marwan G. Fakih explains that KRAS mutations, found in 45% of patients with colorectal cancer, include the rare KRAS G12C mutation, leading to Lumakras approval. According to the National Cancer ...

One in 6 patients with colorectal cancer have an inherited cancer-related gene mutation which likely predisposed them to the disease, according to a Mayo Clinic study. About 16 percent of the 361 ...

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene — a gene that can cause cancer — that may play an important role in colon cancer. Researchers also showed how this ...

A bacterial toxin called colibactin, produced by certain strains of E. coli, appears to alter gut DNA in a way that prompts colon cancer, researchers report in the journal Nature. Photo by ...

The microbial toxin colibactin has just the right shape to snuggle up to DNA — but its embrace is unfortunately more cancerous than cozy. Colibactin is produced by bacteria in the gut and causes ...

Implications for colorectal cancer patients considering immunotherapy Although rare, patients with CRC benefit from identifying the exact type of POLE mutation they might carry. Those with LOP POLE ...