Human colon cancer cell lines RKO (wild-type p53) and SW620 (mutant p53) were purchased from ATCC (Rockville, MD). RKO cells were cultured in RPMI 1640 medium and SW620 cells were cultured in McCoy's ...
Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by combining transcriptome and ...
Topoisomerase I (TOP1) enzymes are essential in higher eukaryotes, as they are required to relax DNA supercoiling generated by transcription, replication and chromatin remodelling. Topoisomerases are ...
Chennai: Indian Institute of Technology Madras (IIT Madras) and IIT Mandi researchers have metabolically engineered the plant cells of Nothapodytes nimmoniana to increase the production of ...
Discovered in 1966, the drug camptothecin comes from the Camptotheca tree native to China. The compound’s ability to inhibit a DNA repair enzyme makes it a cytotoxic agent with cancer-killing effects.
CHENNAI: Indian Institute of Technology Madras Researchers have identified a sustainable and high-yielding alternative source for the anti-cancer drug Camptothecin. This novel microbial fermentation ...
Share on Pinterest A recent study finds that a failed cancer drug reduces appetite and boosts weight loss in mice. lingqi xie/Getty Images Small doses of a drug once considered for treating tumors may ...
A single arm phase II trial of gemcitabine (G) and irinotecan (I) in metastatic breast cancer: Can localization of topoisomerase I (topo I) predict response to topo I inhibitors? This is an ASCO ...
The U.S. Food and Drug Administration has granted Fast Track Designation to a new drug combination for metastatic colorectal cancer, following encouraging results from a clinical trial led in part by ...
Researchers recently completed a study that has the potential to improve cancer treatment for colorectal cancer and melanoma by using nanotechnology to deliver chemotherapy in a way that makes it more ...
Indian Institute of Technology Madras (IIT Madras) and IIT Mandi researchers have metabolically engineered the plant cells of Nothapodytes nimmoniana to increase the production of Camptothecin, a ...
An anti-tumor drug promotes weight loss in mice at low doses by activating a natural hunger-suppressing pathway, according to a new study publishing February 24th in the open-access journal PLOS ...
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