The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Hot and humid climates are particularly conducive to muscle cramps. Studies suggest that athletes, like Sinner, who compete in such conditions are at a higher risk due to the increased sweat loss and ...

IT is well established that an increase in the intracellular concentration of ionized calcium after excitation in the membrane is the key factor for initiation of contraction of various types of ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

Muscle twitches fall into two main types. There’s myoclonus, where a whole muscle or group of muscles twitch or spasm. Then ...

Ferulic acid suppresses ileal smooth muscle contraction by inhibiting calcium ion influx through voltage-dependent calcium channels. This action may help prevent or treat excessive intestinal motility ...