Biopsy-derived cryo-EM structures reveal patient-specific amyloid fibrils

Prof. Liu Cong from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, along with collaborators, has revealed the high-resolution structures of amyloid fibrils directly ...
BioTechniques

Novel microscopy technique provides insights into amyloid architecture

Researchers have developed a microscopy technique to visualize amyloid beta’s underlying structure, which could yield new insights into Alzheimer’s disease. As the prevalence of Alzheimer’s rises, ...
JSTOR Daily

Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer’s disease brain tissue

This is a preview. Log in through your library . Abstract Amyloid-β (Aβ) fibrils exhibit self-propagating, molecular-level polymorphisms that may contribute to variations in clinical and pathological ...
University of Geneva

A skin biopsy to detect a rare neurodegenerative disease

By determining the structure of the deposits responsible for transthyretin amyloidosis through a simple skin biopsy, scientists at UNIGE are paving the way for a new diagnostic method for ...
EurekAlert!

Solving the structure of a functional amyloid protein provides new clues to the origin of a rare disease

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein. A member of the RNA-associated ...
News Medical

Scientists uncover the structure of the first step in amyloid formation for Huntington's disease

Devastating neurodegenerative diseases like Huntington's, Alzheimer's, and Parkinson's are all associated with protein deposits in the brain, known as amyloid. Despite extensive research investment ...
BioTechniques

Cryo-EM reveals an amyloid protein structure associated with a rare disease

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

Molecular arrangement strategy targets multiple Alzheimer's disease factors at once

Conventional treatments of Alzheimer's disease, one of the most common forms of dementia, have been largely focused on targeting individual pathological features. However, Alzheimer's disease is a ...
Drug Target Review

Brain discovery could improve drugs targeting amyloid diseases

Discover how amyloid proteins help form long-term memories according to new research from the Stowers Institute.

A skin biopsy can detect a rare neurodegenerative disease

By determining the structure of the deposits responsible for transthyretin amyloidosis through a simple skin biopsy, ...